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The potency of an agonist can be expressed in terms of the concentration (EC50) at which the effect reaches one-half of its respective maximum. Antagonists (A) attenuate the effect of agonists, that is, their action is “anti-agonistic”. Competitive antagonists possess affinity for receptors, but binding to the receptor does not lead to a change in cell function (zero intrinsic activity).
The bronchi are dilated, enabling tidal volume and alveolar oxygen uptake to be increased. Sweat glands are also innervated by sympathetic fibers (wet palms due to excitement); however, these are exceptional as regards their neurotransmitter (ACh, p. 106). Although the life styles of modern humans are different from those of hominid ancestors, biological functions have remained the same.
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