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This effect is mediated by D1 receptors and is utilized in the treatment of cardiovascular shock and hypertensive emergencies by infusion of dopamine and fenoldopam, respectively. At higher doses, ?1-adrenoceptors and, finally, ?-receptors are activated, as evidenced by cardiac stimulation and vasoconstriction, respectively.
Sympathomimetics can be used systemically in certain types of hypotension and locally for nasal or conjunctival decongestion (pp. 324, 326) or as adjuncts in infiltration anesthesia (p. 206) for the purpose of delaying the removal of local anesthetic. With local use, underperfusion of the vasoconstricted area results in a lack of oxygen (A). |
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