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Ampicillin belongs to a class of antibiotics called penicillins that are used for treating bacterial infections. Other members of this class include amoxicillin (Amoxil), piperacillin (Pipracil), ticarcillin (Ticar) and several others. These antibiotics all have a similar mechanism of action. They stop bacteria from multiplying by preventing bacteria from forming the walls that surround them.
Depending on the pKa, 50 to 5% of the drug may be present at physiological pH in the uncharged lipophilic form. This fraction is important because it represents the lipid membrane-permeable form of the local anesthetic (p. 26), which must take on its cationic amphiphilic form in order to exert its action (p. 204). Clinically used local anesthetics are either esters or amides. |
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