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In renal arterial stenosis, the RAA system may be needed for maintaining renal function and ACE inhibitors may precipitate renal failure. Dry cough is a fairly frequent side effect, possibly caused by reduced inactivation of kinins in the bronchial mucosa. Rarely, disturbances of taste sensation, exanthema, neutropenia, proteinuria, and angioneurotic edema may occur.
Some of the receptors for the transmitter ?-aminobutyric acid (GABA) belong to this receptor family: the GABAA subtype is linked to a chloride channel (and also to a benzodiazepine- binding site, see p. 227). Glutamate and glycine both act via ligandgated ion channels. The insulin receptor protein represents a ligand-operated enzyme (C), a catalytic receptor. |
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