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Risk factors are: premature menopause, physical inactivity, cigarette smoking, alcohol abuse, low body weight, and calcium-poor diet. Prophylaxis: Administration of estrogen can protect against postmenopausal loss of bone mass. Frequently, conjugated estrogens are used.
Hydroxocobalamin is an alternative, very effective antidote because its central cobalt atom binds CN- with high affinity to generate cyanocobalamin. Tolonium chloride (Toluidin Blue). Brown-colored methemoglobin, containing tri- instead of divalent iron, is incapable of carrying O2.

 

Its mechanism of action remains unclear. (In the bacterium it is converted to isonicotinic acid, which is membrane impermeable, hence likely to accumulate intracellularly. ) Isoniazid is rapidly absorbed after oral administration.
As the smallest formed element of blood (dia. 1–4 ?m), they can be activated by various stimuli. Activation entails an alteration in shape and secretion of a series of highly active substances, including serotonin, platelet activating factor (PAF), ADP, and thromboxane A2. In turn, all of these can activate other platelets, which explains the explosive nature of the process.

 

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