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Such collapse sometimes can be prevented by using various matrix-forming excipients such as mannitol than can induce crystallinity and hence, impart rigidity to the amorphous composite. Size of tablet30 The degree of ease when taking a tablet depends on its size. It has been reported that the easiest size of tablet to swallow is 7-8 mm while the easiest size to handle was one larger than 8 mm.
This is so because the activity of elimination processes is concentration- dependent. The higher the drug concentration rises, the greater is the amount eliminated per unit of time. After several doses, the concentration will have climbed to a level at which the amounts eliminated and taken in per unit of time become equal, i. e. , a steady state is reached. |
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