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In Phase II (synthetic) reactions, conjugation products of either the drug itself or its Phase I metabolites are formed, for instance, with glucuronic or sulfuric acid. The special case of the endogenous transmitter acetylcholine illustrates well the high velocity of ester hydrolysis.
The artificial milieu imposed on the tissue. Concentration-Effect Curves (B) As the concentration is raised by a constant factor, the increment in effect diminishes steadily and tends asymptotically towards zero the closer one comes to the maximally effective concentration.

 

The kinetic properties of the latter, however, necessitate adjustment of dosage in the course of treatment, because low dosage during the first days of treatment fails to provide pain relief, whereas high dosage of the drug, if continued, will lead to accumulation into a toxic concentration range (C).
In drug elimination via the kidney, excretion often depends on glomerular filtration, i. e. , the filtered amount of drug present in primary urine. As the blood concentration falls, the amount of drug filtered per unit of time diminishes. The resulting exponential decline is illustrated in (A).

 

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