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Frequent adverse reactions are: damage to skin and mucous membranes, renal toxicity, and blood dyscrasias. In addition, use is made of cytostatics and immune suppressants such as methotrexate (low dose, once weekly) and leflumomid as well as of cytokin antibodies (infliximab) and soluble cytokin receptors (etanercept).
Depending on the condition, use is made of: thiazides, loop diuretics, aldosterone antagonists, and osmotic diuretics. Antihypertensive therapy. Diuretics have long been used as drugs of first choice for lowering elevated blood pressure (p. 312). Even at low dosage, they decrease peripheral resistance (without significantly reducing EFV) and thereby normalize blood pressure.

 

For most therapeutic agents used to produce systemic effects, the oral route still represents the preferred way of administration, owing to its several advantages and high patient compliance compared to many other routes2. Tablets and hard gelatin capsules constitute a major portion of drug delivery systems that are currently available.
Administration of (thiazide) diuretics offers a therapeutic approach of proven efficacy that is brought about by a decrease in circulating blood volume (decreased venous return) and peripheral resistance, i.e., afterload.

 

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