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Even after inhalation, effective amounts can reach the systemic circulation and cause side effects (e. g. , palpitations, tremulousness, restlessness, hypokalemia). During chronic administration, the sensitivity of bronchial musculature is likely to decline. d) Theophylline belongs to the methylxanthines.
Therapeutic objectives are: (1) prevention of life-threatening hyperglycemic (diabetic) coma; (2) prevention of diabetic sequelae (angiopathy with blindness, myocardial infarction, renal failure), with precise “titration” of the patient being essential to avoid even short-term spells of pathological hyperglycemia.

 

Inhibition of exocrine glands Bronchial secretion. Premedication with atropine before inhalation anesthesia prevents a possible hypersecretion of bronchial mucus, which cannot be expectorated by coughing during intubation (anesthesia). Gastric secretion.
Because of its high potency, fentanyl is suitable for transdermal delivery (A). In opiate abuse, “smack” (“junk,” “jazz,” “stuff,” “China white;” mostly heroin) is self administered by injection (“mainlining”) so as to avoid first-pass metabolism and to achieve a faster rise in brain concentration.

 

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