Drug Name Tetracycline

The mechanism of action is known for some of them: pyrimethamine and dapsone inhibit dihydrofolate reductase, as does chlorguanide (proguanil) via its active metabolite. The sulfonamide sulfadoxine inhibits synthesis of dihydrofolic acid.
Absorption from the intestine causes the drug concentration in blood to increase. Transport in blood conveys the drug to different organs (distribution), into which it is taken up to a degree compatible with its chemical properties and rate of blood flow through the organ. For instance, well-perfused organs such as the brain receive a greater proportion than do less well-perfused ones.

 

Deficient dopaminergic transmission in the striatum can be compensated by ergot derivatives (bromocriptine [p. 114], lisuride, cabergoline, and pergolide) and nonergot compounds (ropinirole, pramipexole). These agonists stimulate dopamine receptors (D2, D3, and D1 subtypes), have lower clinical efficacy than levodopa, and share its main adverse effects. Inhibitors of monoamine oxidase- B (MAOB).
As “slow-reacting substances of anaphylaxis,” they are involved in allergic reactions; together with PG, they evoke the spectrum of characteristic inflammatory symptoms: redness, heat, swelling, and pain. Therapeutic applications. PG derivatives are used to induce labor or to interrupt gestation (p. 126); in the therapy of peptic ulcer, and in peripheral arterial disease.