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Deficient dopaminergic transmission in the striatum can be compensated by ergot derivatives (bromocriptine [p. 114], lisuride, cabergoline, and pergolide) and nonergot compounds (ropinirole, pramipexole). These agonists stimulate dopamine receptors (D2, D3, and D1 subtypes), have lower clinical efficacy than levodopa, and share its main adverse effects. Inhibitors of monoamine oxidase- B (MAOB).
Treatment of advanced disease requires the combined administration of antiparkinsonian agents. Epilepsy is a chronic brain disease of diverse etiology; it is characterized by recurrent paroxysmal episodes of uncontrolled excitation of brain neurons. |
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