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Internal sleep cycles recur 4 to 5 times per night, each cycle being interrupted by a Rapid Eye Movement (REM) sleep phase (A). The REM stage is characterized by EEG activity similar to that seen in the waking state, rapid eye movements, vivid dreams, and occasional twitches of individual muscle groups against a background of generalized atonia of skeletal musculature.
Before prescribing a drug, the physician should therefore assess the risk: benefit ratio. In this, knowledge of principal and adverse effects is a prerequisite. The immune system normally functions to rid the organism of invading foreign particles, such as bacteria.

 

Symptomatic treatment in parkinsonism for the purpose of restoring a dopaminergic-cholinergic balance in the corpus striatum. Antiparkinsonian agents, such as benzatropine, readily penetrate the blood-brain barrier. At centrally equi-effective dosage, their peripheral effects are less marked than are those of atropine.
Contrary to timed-release capsules , slow-release tablets have the advantage of being dividable ad libitum; thus, fractions of the dose contained within the entire tablet may be administered. This kind of retarded drug release is employed when a rapid rise in blood level of drug is undesirable.

 

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